The synthesis and biological importance of some new seriesof benzofuran derivatives were reported. Condensation reaction of 2-hydroxy–benzonirile with ethylchloroacetate in the presence of dry potassium carbonate in dry acetone affords ethyl 3-amino-1-benzofuran-2-carboxylate 2. The reaction of compound 2 on treatment with hydrazine hydrate afforded compound 3 with excellent yield. The synthesis of 1,3,4-oxadiazol derivatives 4a-e have been achieved by direct cyclisation of 3-amino-1-benzofuran-2-carbohydrazide(3) with various fatty acids in the presence of POCl3. The structures of all newly synthesized compounds were confirmed by IR, 1H NMR, and Mass spectral data. Newly synthesized compounds were screened analgesic and antimicrobial activity. Compounds 4a and 4b proved to be efficient in their action comparable to standard drug acetyl salicylic acid. This investigation revealed that the synthesized compounds are potential anti bacterial and antinociceptive agents.
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